凋亡相关蛋白TGFb信号抗体
规格：1mg/1ml
英文名： ARTS/SEPT4
别名： Apoptosis Related Protein TGFb Signalling; Apoptosis-related protein in the TGF-beta signaling pathway; ARTS; bradeion; Bradeion beta; Brain protein H5; CE5B3; CE5B3 beta; cell division control-relate
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ARTS (91
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
凋亡相关蛋白TGFb信号抗体产品介绍：background: This gene is a member of the septin family of nucleotidebinding proteins, originally described in yeast as cell divisioncycle regulatory proteins. Septins are highly conserved in yeast,Drosophila, and mouse, and appear to regulate cytoskeletalorganization. Disruption of septin function disturbs cytokinesisand results in large multinucleate or polyploid cells. This gene ishighly expressed in brain and heart. Alternatively splicedtranscript variants encoding different isoforms have been describedfor this gene. One of the isoforms (known as ARTS) is distinct; itis localized to the mitochondria, and has a role in apoptosis andcancer. [provided by RefSeq, Nov 2010]. Function: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. Subunit: Septins polymerize into heterooligomeric proteincomplexes that form filaments, and can associate with cellularmembranes, actin filaments and microtubules. GTPase activity isrequired for filament formation (By similarity). Interacts withSEPT8. In a mesenchymal凋亡相关蛋白TGFb信号抗体 cell line, interacts with SEPT9 isoform 2variants HNA Trp-106 and Phe-111, but not the wild type SEPT9.Isoform ARTS, but no other isoforms, interacts with XIAP after theinduction of apoptosis. Subcellular Location: Cytoplasm (By similarity). Cytoplasm,cytoskeleton (By similarity). Note=In platelets, found in areassurrounding alpha-granules. Isoform ARTS: Mitochondrion. Nucleus.Note=While predominantly localized in the mitochondria underresting conditions, isoform ARTS translocates into the nucleusafter TGF-beta treatment and apoptosis induction. Tissue Specificity: Widely expressed in ***** and fetal tissueswith highest expression in ***** brain (at protein level), heart,liver and adrenal gland and fetal heart, kidney, liver and lung.Also expressed in colorectal cancers and malignant melanomas.Expressed in platelets. Post-translational modifications凋亡相关蛋白TGFb信号抗体: N-glycosylated. Similarity: Belongs to the peptidase M1 family. Database links: Entrez Gene: 538801 Cow Entrez Gene: 480571 Dog Entrez Gene: 5414 Human Entrez Gene: 18952 Mouse Entrez Gene: 287606 Rat Omim: 603696 Human SwissProt: O43236 Human SwissProt: P28661 Mouse Unigene: 287518 Human Unigene: 2214 Mouse Unigene: 6269 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产凋亡相关蛋白TGFb信号抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞凋亡 细胞周期蛋白
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid
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