细胞质分裂付出蛋白1抗体
规格：1mg/1ml
英文名： DOCK1
别名： 180 kDa protein downstream of CRK; Ced5; Dedicator of Cytokinesis 1; Dedicator of cytokinesis protein 1; DOCK 1; DOCK-1; DOCK 180; DOCK1; DOCK1_HUMAN; DOCK180.
分子量： 215kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DOCK1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
细胞定位：细胞浆 细胞膜
细胞质分裂付出蛋白1抗体产品介绍：background: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. Tissue specificity: Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon. Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. Subunit: Interacts with the SH3 domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1 via its DHR-2 domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 and BAI1. Subcellular Location: Cytoplasm (Probable). Membrane (Probable). Note=Recruited to membranes via its interaction with 细胞质分裂付出蛋白1抗体phosphatidylinositol 3,4,5-trisphosphate (Probable). Tissue Specificity: Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon. Similarity: Belongs to the DOCK family. Contains 1 DHR-1 domain. Contains 1 DHR-2 domain. Contains 1 SH3 domain. Gene ID: 1793 Database links: Entrez Gene: 1793 Human Entrez Gene: 330662 Mouse Entrez Gene: 309081 Rat Omim: 601403 Human SwissProt: Q14185 Human SwissProt: Q8BUR4 Mouse Unigene: 159195 Human Unigene: 645702 Human Unigene: 436572 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 乳腺癌转移的新标记物DOCK1 乳腺癌是一种常常发生转移的癌症。将近90%的乳腺癌患者都因为癌症扩散而死，因此，理解这一危险过程的细胞和分子基础机制是十分重要的。 近日，加拿大蒙特利尔临床研究所（Institut de recherches cliniques de Montreal, IRCM）细胞质分裂付出蛋白1抗体的科学家在乳腺癌研究方面取得了一个重要的发现，他们确定了，一种名为DOCK1的蛋白质可以作为潜在的靶标用于减少乳腺癌患者的癌转移。相关研究结果刊登在了近期出版的《PNAS》上。 研究人员在乳腺癌**方面尽管已经取得了重要的进展，但是对于癌症扩散的机制却知之甚少。科学家正在试图确定能够调节癌转移过程的蛋白质，因为它们或许可以作为新的**靶标，并与现有的方法相结合促进**的效果。 在这项研究中，2个主要的癌症亚型——HER-2+型和Basal-like型，很容易转移和复发，并*终导致患者的低生存率。该调查以HER-2+(人类表皮生长因子受体2)型为研究对象， 这代表了大约25%的乳腺癌病例。 HER2阳性肿瘤比其它类型的肿瘤更倾向于快速的发展和扩散。 研究人员解释到，通过研究HER2+乳腺癌小鼠模型，确定了DOCK1蛋白质是癌转移的一个重要的调控因子。当去除了小鼠中的这一蛋白质后，乳腺癌的肺转移大大减少了。此外，研究发现DOCK1蛋白质有助于肿瘤的生长。 为了证明DOCK1的表达与乳腺癌预后之间的关系，研究人员对包含患者基因信息的几个数据库进行了分析。结果发现，在HER-2+型或Basal-like型乳腺癌中，高水平的DOCK1与较差的预后以及**的复发有关。
细胞质分裂付出蛋白1抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞凋亡 细胞自噬 G蛋白信号
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid