凋亡加强结构域蛋白4抗体
规格：1mg/1ml
英文名： CARD4
别名： CARD 4; CARD4; Caspase recruitment domain 4; Caspase recruitment domain containing protein 4; Caspase recruitment domain family member 4; Caspase recruitment domain protein 4; Caspase recruitment doma
分子量： 108kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CARD4
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 细胞膜
凋亡加强结构域蛋白4抗体产品介绍：background: Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Subunit: Homodimer. Self-associates. Binds to caspase-9 and RIPK2 by 凋亡加强结构域蛋白4抗体CARD-CARD interaction. Interacts with ARHGEF2. Subcellular Location: Cytoplasm. Basolateral cell membrane. Recruited to the basolateral membrane compartment in polarized epithelial cells. Tissue Specificity: Highly expressed in ***** heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon. Similarity: Contains 1 CARD domain凋亡加强结构域蛋白4抗体. Contains 9 LRR (leucine-rich) repeats. Contains 1 NACHT domain. Database links: Entrez Gene: 10392 Human Entrez Gene: 107607 Mouse Entrez Gene: 500133 Rat Omim: 605980 Human SwissProt: Q9Y239 Human SwissProt: Q8BHB0 Mouse Unigene: 405153 Human Unigene: 28498 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产凋亡加强结构域蛋白4抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid