细胞分裂核仁蛋白1抗体
规格：1mg/1ml
英文名： DENTT
别名： CASK interacting nucleosome assembly protein; CINAP; CDA1; Cell division autoantigen 1 nucleolar protein; CTCL tumor antigen se20-4; DENTT; Differentially-expressed nucleolar TGF-beta1 target protein;
分子量： 76kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DENTT
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核 细胞浆
细胞分裂核仁蛋白1抗体产品介绍：background: CASK interacting nucleosome assembly protein (CINAP) modulates gene expression and its abundance in cultured neurons is regulated by synaptic activity. CINAP is widely expressed in different regions of ***** mouse brain, including the cerebral cortex, hippocampus, striatum, hypothalamus, cerebellum, and two ***** brain regions known to generate progenitor neurons. During early development, CINAP is also expressed in regions where neuronal progenitor cells are actively dividing, the ventricular and subventricular zones, suggesting that in addition to regulating gene expression in mature neurons CINAP may also play a role in dividing cells. Function: Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably 细胞分裂核仁蛋白1抗体by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. Subunit: Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TRB1 and TSPYL2. Subcellular Location: Nucleus. Cytoplasm. Note=Enriched in transcriptionally active regions of chromatin in neurons. Tissue Specificity: Ubiquitously expressed, with highest levels in brain, testis and细胞分裂核仁蛋白1抗体 heart, and lowest levels in liver and pancreas. Post-translational modifications: Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation (Probable). Similarity: Belongs to the nucleosome assembly protein (NAP) family. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产细胞分裂核仁蛋白1抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid