细胞周期及凋亡调节蛋白1抗体
规格：1mg/1ml
英文名： DIS
别名： CARP-1; Carp1; CCAR1; CCAR1_HUMAN; Cell cycle and apoptosis regulatory protein 1; cell division cycle and apoptosis regulator 1; Cell division cycle and apoptosis regulator protein 1; Death Inducer wi
分子量： 133kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DIS/CCAR
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆
细胞周期及凋亡调节蛋白1抗体产品介绍：background: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. Function: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator细胞周期及凋亡调节蛋白1抗体 proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. Subunit: Directly interacts with CALCOCO1, ESR1, NR3C1 and TP53 (By similarity). Subcellular Location: Cytoplasm,细胞周期及凋亡调节蛋白1抗体 perinuclear region. Tissue Specificity: Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors. Similarity: Contains 1 SAP domain. Gene ID: 55749 Database links: Entrez Gene: 423692 Chicken Entrez Gene: 450498 Chimpanzee Entrez Gene: 767587 Cow Entrez Gene: 479230 Dog Entrez Gene: 55749 Human Entrez Gene: 67500 Mouse Entrez Gene: 361849 Rat Omim: 612569 Human SwissProt: Q8IX12 Human SwissProt: Q8CH18 Mouse SwissProt: D3ZG47 Rat Unigene: 49853 Human Unigene: 196371 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产细胞周期及凋亡调节蛋白1抗体品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞凋亡 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid