FK506结合蛋白相关蛋白抗体
规格：1mg/1ml
英文名： GLMN
别名： FAP; FAP48; FAP68; FK506 binding protein associated protein; FKBP associated protein; FKBPAP; GLML; GLMN; Glomulin; GVM; VMGLOM.
分子量： 68 kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GLMN/FK5
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse,
细胞定位：
FK506结合蛋白相关蛋白抗体产品介绍：background: GLMN is a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Alternatively spliced variants that encode different protein isoforms have been described but the full length nature of only one has been determined. GLMN may represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12 and may function as an membrane anchoring protein. Isoform 1 may stimulate the p70S6K pathway. Isoform 2 may inhibit cell proliferation and increase IL2 production. Function: Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. Isoform 1 may stimulate the p70S6K pathway. Isoform 2 FK506结合蛋白相关蛋白抗体may inhibit cell proliferation and increase IL2 production. Subunit: Monomer. Isoform 1 interacts with notphosphorylated MET and is released upon receptor phosphorylation. Isoform 2 interacts with FKBP59 and FKBP12. Isoform 1 is part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN isoform 1. Tissue Specificity: Ubiquitous. Post-translational modifications: Phosphorylated on tyrosine residues. DISEASE: Defects in GLMN are the cause of glomuvenous malformations (GVMs) [MIM:138000]. GVMs are characterized by the presence of smooth-muscle-like glomus cells in the media surrounding distended vascular lumens. Database links: Entrez Gene: 504211 Cow Entrez Gene:FK506结合蛋白相关蛋白抗体 11146 Human Entrez Gene: 170823 Mouse GenBank: NP_444504.1 Human Omim: 601749 Human SwissProt: Q92990 Human SwissProt: Q8BZM1 Mouse Unigene: 49105 Human Unigene: 41417 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产FK506结合蛋白相关蛋白抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：干细胞 血管内皮细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid