G蛋白结合蛋白5抗体
规格：1mg/1ml
英文名： GBP5
别名： GBP 5; GBP-5; GBP TA antigen; GBP5; GBP-TA antigen; GBP5; GBP5_HUMAN; GTP binding protein 5; GTP-binding protein 5; Guanine nucleotide binding protein 5; Guanine nucleotide-binding protein 5; Guanylat
分子量： 66kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GBP5/Gua
交叉反应：Human,
细胞定位：细胞浆 细胞膜
G蛋白结合蛋白5抗体产品介绍：background: GBP5 is a 586 amino acid protein that localizes to the cytoplasmic side of the cell membrane. Belonging to the interferon (IFN)-inducible guanylate-binding protein (GBP) family, GBP5 may be involved in the inflammatory response or with cell proliferation and is suggested to have possible cancer-related functions. The gene encoding GBP5 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, G蛋白结合蛋白5抗体Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma. Function: Stimulates the NLRP3 inflammasome assembly upon bacterial challenge. Subunit: Homotetramer when interacting with NLRP3 (By similarity). Homodimerizes upon GTP-binding, dimerization is G蛋白结合蛋白5抗体required for the second hydrolysis step from GDP to GMP. Can also heterodimerize with other members of the family. Homotetramer when interacting with NLRP3. Subcellular Location: Cytoplasm. Membrane; Lipid-anchor. Similarity: Belongs to the GBP family. Database links: UniProtKB/Swiss-Prot: Q96PP8.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产G蛋白结合蛋白5抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 转录调节因子 G蛋白信号 干扰素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid