己糖6磷酸脱氢酶抗体
规格：1mg/1ml
英文名： G6PDH
别名： 6 phosphogluconolactonase; 6-phosphogluconolactonase; 6PGL; H6PD; DKFZp686A01246; G6PD H form; G6PDH; G6PE_HUMAN; GDH; H6PD; GDH/6PGL endoplasmic bifunctional protein; Glucose 1 dehydrogenase; Glucose
分子量： 85kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human G6PDH
交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit,
细胞定位：细胞浆
己糖6磷酸脱氢酶抗体产品介绍：background: H6PD (hexose-6-phosphate dehydrogenase, GDH/6PGL endoplasmic bifunctional protein) is a 789 amino acid protein encoded by the human gene H6PD. The N-terminal section of H6PD belongs to the glucose-6-phosphate dehydrogenase family, while the C-terminal section belongs to the glucosamine/galactosamine-6-phosphate isomerase family, 6-phosphogluconolactonase subfamily. H6PD is responsible primarily for the oxidation of glucose-6-phosphate and glucose. It also oxidizes other hexose-6-phosphates. H6PD catalyzes the conversion of glucose 6-phosphate to 6-phosphogluconolactone within the lumen of the endoplasmic reticulum, thereby generating reduced nicotinamide adenine dinucleotide phosphate. Reduced nicotinamide adenine dinucleotide phosphate is a necessary cofactor for the reductase activity of 11∫-hydroxysteroid dehydrogenase type 1, which converts hormonally inactive cortisone to active cortisol (in rodents, 11-dehydrocorticosterone to corticosterone). Function: Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates. Subcellular Location: Endoplasmic reticulum lumen. Note=Microsomes, endoplasmic reticulum lumen. Tissue Specificity: Present in most tissues examined, strongest in liver.己糖6磷酸脱氢酶抗体 DISEASE: Defects in H6PD are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS). Similarity: In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family. In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. Gene ID: 9563 Database links:己糖6磷酸脱氢酶抗体 Entrez Gene: 25796 Human Entrez Gene: 9563 Human Entrez Gene: 100198 Mouse Entrez Gene: 66171 Mouse Entrez Gene: 290636 Rat Entrez Gene: 298655 Rat Omim: 138090 Human Omim: 604951 Human SwissProt: O95336 Human SwissProt: O95479 Human SwissProt: Q8CFX1 Mouse SwissProt: Q9CQ60 Mouse SwissProt: P85971 Rat Unigene: 463511 Human Unigene: 466165 Human Unigene: 22183 Mouse Unigene: 282284 Mouse Unigene: 402679 Mouse Unigene: 17292 Rat Unigene: 19855 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
己糖6磷酸脱氢酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid