磷酯酶Cβ1抗体
规格：1mg/1ml
英文名： Phospholipase C beta 1
别名： 1-phosphatidylinositol-45-bisphosphate phosphodiesterase beta 1; 1vphosphatidylinositol 4,5 bisphosphate phosphodiesterase beta 1 ; Phosphb; Phosphoinositide phospholipase C; Phosphoinositide phosphol
分子量： 134kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Phosphol
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse,
细胞定位：细胞核 细胞浆 细胞膜
磷酯酶Cβ1抗体产品介绍：background: Phospholipase C beta 1 catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. Its gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for its gene. Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Subunit: Interacts with DGKQ. Subcellular Location: Cytoplasmic and Nuclear. DISEASE: Defects in PLCB1 are the cause of epileptic encephalopathy early infantile type 12 磷酯酶Cβ1抗体(EIEE12) [MIM:613722]. EIEE12 is a form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG. Similarity: Contains 1 C2 domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain. Database links: Entrez Gene: 287026 Cow Entrez Gene:磷酯酶Cβ1抗体 23236 Human Entrez Gene: 18795 Mouse Entrez Gene: 24654 Rat Omim: 607120 Human SwissProt: P10894 Cow SwissProt: Q9NQ66 Human SwissProt: Q9Z1B3 Mouse SwissProt: P10687 Rat Unigene: 431173 Human Unigene: 330607 Mouse Unigene: 45523 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酯酶Cβ1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-300 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid