赖氨酸，天冬氨酸，谷氨酸，亮氨酸相关序列抗体
规格：1mg/1ml
英文名： KDEL
别名： KDEL; Lys Asp Glu Leu antibody; GRP 78; GRP 94; KDEL1_HUMAN.
分子量： 78kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide KDEL
交叉反应：Human, Mouse, Dog, Pig, Cow, Rabbit, Guinea Pig,
细胞定位：细胞浆
赖氨酸，天冬氨酸，谷氨酸，亮氨酸相关序列抗体产品介绍：background: Endoplasmic reticulum Marker. The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble endoplasmic reticulum (ER) resident proteins and some membrane proteins. 78 and 94 kDa glucose regulated proteins (GRP 78) and GRP 94 respectively and protein disulfide isomerase (PDI) all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor. Function: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Subunit: Interacts with DNAJC1 (via J domain). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part a large chaperone multiprotein 赖氨酸，天冬氨酸，谷氨酸，亮氨酸相关序列抗体complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A and TRIM21. May form a complex with ERLEC1, OS9, SEL1L and SYVN1. Subcellular Location: Endoplasmic reticulum. DISEASE: Note=Autoantigen in rheumatoid arthritis赖氨酸，天冬氨酸，谷氨酸，亮氨酸相关序列抗体. Similarity: Belongs to the heat shock protein 70 family. Gene ID: 79070 Database links: Entrez Gene: 79070 Human Entrez Gene: 72050 Mouse Entrez Gene: 316370 Rat Omim: 611613 Human SwissProt: Q6UW63 Human SwissProt: Q9JHP7 Mouse SwissProt: B5DFA5 Rat Unigene: 408629 Human Unigene: 281714 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 内质网标志物。
赖氨酸，天冬氨酸，谷氨酸，亮氨酸相关序列抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid