纤维蛋白原γ链抗体
规格：1mg/1ml
英文名： Fibrinogen gamma chain
别名： FGG; FIBG_HUMAN; Fibrinogen gamma chain; Fibrinogen gamma polypeptide; fibrinogen gamma-b chain.
分子量： 47kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Fibrinog
交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit,
细胞定位：分泌型蛋白
纤维蛋白原γ链抗体产品介绍：background: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Involvement in disease: Defects in FGG are a cause of thrombophilia. Defects in FGG are a cause of congenital afibrinogenemia (CAFBN). It is a rare autosomal recessive disorder characterized by complete absence of detectable fibrinogen. Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Subunit: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain. Subcellular Location: Secreted. Post-translational modifications: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Sulfation of C-terminal tyrosines increases affinity for thrombin. DISEASE: Defects in FGG are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This rare纤维蛋白原γ链抗体 autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.纤维蛋白原γ链抗体 Similarity: Contains 1 fibrinogen C-terminal domain. Gene ID: 2266 Database links: Entrez Gene: 2266 Human Entrez Gene: 99571 Mouse Omim: 134850 Human SwissProt: P02679 Human SwissProt: Q8VCM7 Mouse Unigene: 16422 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
纤维蛋白原γ链抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid