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细胞周期调控相关蛋白1

细胞周期调控相关蛋白1
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  • 产品名称:细胞周期调控相关蛋白1
  • 产品型号:CDCREL
  • 产品展商:单克隆抗体/多克隆抗体
  • 产品文档:无相关文档
简单介绍
细胞周期调控相关蛋白1应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。细胞周期调控相关蛋白1生产每个流程都执行严格的检测标准,保证蛋白抗原产品质量,质量稳定,实验效果明显。
产品描述

细胞周期调控相关蛋白1

规格:1mg/1ml

英文名: CDCREL

别名: 5 Sep; CDCrel 1; CDCREL; CDCrel-1; CDCREL1; Cell division control related protein 1; Cell division control-related protein 1; H5 antibody HCDCREL 1; Peanut like 1; Peanut like 1 homolog; Peanut like p

分子量: 41kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:Polyclonal

亚型:IgG

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human CDCREL/S

交叉反应:Human, Mouse, Rat, Dog, Pig, Cow, Horse,

细胞定位:细胞浆

细胞周期调控相关蛋白1品介绍:background: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010]. Function: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in platelet secretion. Subunit: Septins polymerize into heterooligomeric protein 细胞周期调控相关蛋白1complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT2 and SEPT5. In platelets, associated with a complex containing STX4. Interacts with PARK2. This interaction leads to SEPT5 ubiquitination and degradation. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton. Note=In platelets, found in areas surrounding alpha-granules Tissue Specificity: Expressed at high levels in the CNS, as well s in heart and platelets (at protein level). Post-translational modifications: In platelets, phosphorylated in response to thrombin, phorbol-12-myristate-13-acetate and collagen. Similarity: Belongs to the septin family.细胞周期调控相关蛋白1 Database links: UniProtKB/Swiss-Prot: Q99719.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. SEPTIN(SEPT)家族是细胞骨架蛋白的一种,具有GTPase的活性。经研究发現,SEPT参与细胞的分裂、细胞膜的运输以及构成细胞骨架。SEPTIN5又称细胞骨架蛋白SEPT5。

细胞周期调控相关蛋白1品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:细胞生物  **学  细胞周期蛋白  细胞分化  细胞骨架  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid




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