电压门控钠通道SCN3B蛋白抗体
规格：1mg/1ml
英文名： SCN3B
别名： SCNB3; Sodium channel, beta 3 subunit; sodium channel, voltage-gated, type III, beta; SCN3B_HUMAN.
分子量： 22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SCN3B
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：
电压门控钠通道SCN3B蛋白抗体产品介绍：background: SCN3B is one member of the sodium channel beta subunits of voltage-gated sodium channels, which are responsible for the generation and propagation of action potentials in neurons and muscle. SCN3B influences the inactivation kinetics of the sodium channel. Function: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). Subunit: The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2 and/or beta-3 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Beta-1 or beta-3 subunits associate with neurofascin.电压门控钠通道SCN3B蛋白抗体 Associates with SCN10A (By similarity). DISEASE: Brugada syndrome 7 (BRGDA7) [MIM:613120]: A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die 电压门控钠通道SCN3B蛋白抗体in a few minutes if the heart is not reset. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Database links: UniProtKB/Swiss-Prot: Q9NY72.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
电压门控钠通道SCN3B蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 信号转导 细胞凋亡 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid