半胱胺酸蛋白酶4/11抗体
规格：1mg/1ml
英文名： Caspase 4+Caspase 11
别名： CASP11; CASP11; Casp4; Caspase 11; Caspase11; Caspase-11; Caspase 4; Caspase4; Caspase-4; Caspase 4 apoptosis related cysteine peptidase; CASPL; CASPL; Ich3; ICH3 protease; ICH3 protease.
分子量： 20kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse Caspase-
交叉反应：Mouse, Rat,
细胞定位：
半胱胺酸蛋白酶4/11抗体产品介绍：background: Caspase 11 (also known as ICH3) gene encodes two protein products of 38 and 43 kDa that belong to the Ced3/ICE family of cysteine proteases. Caspase 11 is an “upstream” caspase with a long prodomain. It undergoes a cleavage upon activation, leading to p20 and p10 subunits. Monoclonal antibodies reacting specifically with caspase 11 are useful tools for the study of the protease network, involved in development and regulation, governing the life and death of cells and tissues. Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Promotes IL-1 beta processing by ICE, so may also have a role in inflammatory responses. Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20)半胱胺酸蛋白酶4/11抗体 and a 10 kDa (p10) subunit. Tissue Specificity: Mostly expressed in lung and spleen; weaker in heart and lung; little in liver, skeletal muscle, kidney and testis. Not found in the brain. Post-translational modifications: The two subunits are derived from the precursor sequence by a autocatalytic mechanism. Similarity: Belongs to the peptidase C14A family. Contains 1 CARD domain. Gene ID: 12363 半胱胺酸蛋白酶4/11抗体Database links: Entrez Gene: 837 Human Entrez Gene: 12363 Mouse Omim: 602664 Human SwissProt: P49662 Human SwissProt: P70343 Mouse Unigene: 138378 Human Unigene: 1569 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
半胱胺酸蛋白酶4/11抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid