谷氧还蛋白/巯基转移酶抗体
规格：1mg/1ml
英文名： Glutaredoxin 1
别名： Glrx; Glrx1; GLRX1_HUMAN; Glutaredoxin; Glutaredoxin-1; Glutaredoxin1; Grx 1; Grx; Grx1; Thioltransferase 1; Thioltransferase; Thioltransferase-1; Thioltransferase1; TTase; TTase 1; TTase-1; TTase1.
分子量： 12kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Glutared
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
谷氧还蛋白/巯基转移酶抗体产品介绍：background: This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]. Function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Subcellular Location: Cytoplasm. Similarity: Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain. Gene ID: 2745 Database links: Entrez Gene: 515416 Cow Entrez Gene: 2745 Human Entrez Gene: 93692 Mouse Entrez Gene: 397463 Pig Entrez Gene: 64045 Rat Omim: 600443 Human SwissProt: P10575 Cow SwissProt: P35754 Human SwissProt: Q9QUH0 Mouse 谷氧还蛋白/巯基转移酶抗体SwissProt: P12309 Pig SwissProt: P12864 Rabbit SwissProt: Q9ESH6 Rat Unigene: 28988 Human Unigene: 712696 Human Unigene: 25844 Mouse Unigene: 1484 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 谷氧还蛋白（Glutaredoxin，简称为GRX）是一类小型的氧化还原酶，为大约只有一百个谷氧还蛋白/巯基转移酶抗体氨基酸残基的单链蛋白质，并以谷胱甘肽作为辅因子。谷氧还蛋白被底物氧化，而非酶促地被谷胱甘肽还原。与可被硫氧还蛋白还原酶还原的硫氧还蛋白相反，并不存在特异性还原谷氧还蛋白的氧化还原酶。取而代之的是，谷氧还蛋白通过去氧化谷胱甘肽来被还原。被氧化的谷胱甘肽接下来被谷胱甘肽还原酶重生出来。NADPH、谷胱甘肽、谷胱甘肽还原酶和谷氧还蛋白这些组件组合在一起的氧化还原网络构成了谷胱甘肽系统。
产谷氧还蛋白/巯基转移酶抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid