黑色素瘤相关抗原D1抗体
规格：1mg/1ml
英文名： MAGED1
别名： DLXIN 1; MAGD1_HUMAN; MAGE D1 antigen; MAGE tumor antigen CCF; MAGE-D1 antigen; Maged1; Melanoma antigen family D 1; Melanoma associated antigen D1; Melanoma-associated antigen D1; Neurotrophin recept
分子量： 85kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAGED1
交叉反应：Human, Mouse, Rat,
细胞定位：
黑色素瘤相关抗原D1抗体产品介绍：background: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate p53 transcriptional activity and inhibit cell proliferation. Enhances p53 phosphorylation and accumulation. Function: Involved in the apoptotic response after nerve growthfactor (NGF) binding in neuronal cells. Binds NGFR/p75NTR andantagonizes its association with NTRK1/TrkA, inhibits cell cycleprogression, and facilitates NGFR-mediated apoptosis. May act as aregulator of the function of DLX family members. May regulateTP53/p53 transcriptional activity and inhibit cell proliferation.Enhances TP53 phosphorylation and accumulation. May enhanceubiquitin ligase activity of RING-type zinc finger-containing E3ubiquitin-protein ligases. Proposed to act through recruitmentand/or stabilization of the Ubl-conjugating enzyme (E2) at theE3:substrate complex. Subunit: Interacts with DLX5, DLX7 and MSX2黑色素瘤相关抗原D1抗体 and formshomomultimers. Interacts with UNC5A (By similarity). Interacts withthe p75 neurotrophin receptor. Interacts with TRIM28 and PJA1. Subcellular Location: Cytoplasm (By similarity). Cell membrane;Peripheral membrane protein (By similarity). Note=Expression shiftsfrom the cytoplasm to the plasma membrane upon stimulation with NGF(By similarity). Tissue Specificity: Expressed in bone marrow stromal cells fromboth multiple myeloma patients and healthy donors. Seems to beubiquitously expressed. Similarity: Contains 1 MAGE domain. Gene ID: 黑色素瘤相关抗原D1抗体9500 Database links: Entrez Gene: 9500 Human Entrez Gene: 94275 Mouse Entrez Gene: 84469 Rat Omim: 300224 Human SwissProt: Q9Y5V3 Human SwissProt: Q9QYH6 Mouse SwissProt: Q9ES73 Rat Unigene: 5258 Human Unigene: 27578 Mouse Unigene: 54596 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
黑色素瘤相关抗原D1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid