TAP1抗体

TAP1抗体经ICC, IHC严格验证,品质保证.适用于多种种属反应性,被多篇文献引用并有用户反馈信息.确保特异性!产品具有以下特点:

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产品编号xy-10632R

英文名称TAP1

中文名称ATP结合转运因子1抗体

别    名ABC transporter MHC 1; ABC17; ABCB 2; ABCB2; Antigen peptide transporter 1; APT 1; APT1; ATP binding cassette sub family B (MDR/TAP) member 2; ATP binding cassette sub family B member 2; ATP binding cassette transporter; D6S114E; FLJ26666; FLJ41500; Peptide supply factor 1; Peptide transporter involved in antigen processing 1; Peptide transporter PSF 1; Peptide transporter PSF1; Peptide transporter TAP 1; Peptide transporter TAP1; PSF 1; PSF1; RING 4; RING4; TAP 1; TAP1*0102N; TAP1N; Transporter 1 ATP binding cassette sub family B (MDR/TAP); Transporter 1 ATP binding cassette sub family B; Transporter 1 ATP Binding Cassette Sub-Family B; Transporter associated with antigen processing; Transporter ATP binding cassette major histocompatibility complex 1; Y3; TAP1_HUMAN.  

说 明 书100ul  200ul

研究领域**学  转录调节因子  

抗体来源Rabbit

克隆类型Polyclonal

TAP1抗体交叉反应 Human, Mouse, Rat, Chicken, Cow, Horse,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量87kDa

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from human TAP1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

产品介绍background:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.

Function:

Involved in the transport of antigens from the cytoplasmto the endoplasmic reticulum for association with MHC class Imolecules. Also acts as a molecular scaffold for the final stage ofMHC class I folding, namely the binding of peptide. Nascent MHCclass I molecules associate with TAP via tapasin. Inhibited by thecovalent attachment of herpes simplex virus ICP47 protein, whichblocks the peptide-binding site of TAP. Inhibited by humancytomegalovirus US6 glycoprotein, which binds to the lumenal sideof the TAP complex and inhibits peptide translocation byspecifically blocking ATP-binding to TAP1 and prevents theconformational rearrangement of TAP induced by peptide binding.Inhibited by human adenovirus E3-19K glycoprotein, which binds theTAP complex and acts as a tapasin inhibitor, preventing MHC classI/TAP association. Expression of TAP1 is down-regulated by humanEpstein-Barr virus vIL-10 protein, thereby affecting the transportof peptides into the endoplasmic reticulum and subsequent peptideloading by MHC class I molecules.

Subunit:

Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barrvirus BNLF2a. Interacts with PSMB5 and PSMB8.

Subcellular Location:

Endoplasmic reticulum membrane; Multi-passmembrane protein. Note=The transmembrane segments seem to form apore in the membrane.

DISEASE:

Bare lymphocyte syndrome 1 (BLS1) [MIM:604571]: A HLAclass I deficiency. Contrary to bare lymphocyte syndromes type 2and type 3, which are characterized by early-onset severe combinedimmunodeficiency, class I antigen deficiencies are not accompaniedby particular pathologic manifestations during the first years oflife. Systemic infections have not been described. Chronicbacterial infections, often beginning in the first decade of life,are restricted to the respiratory tract. Note=The disease is causedby mutations affecting the gene represented in this entry.

Similarity:

Belongs to the ABC transporter superfamily. ABCBfamily. MHC peptide exporter (TC 3.A.1.209) subfamily.

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

Gene ID:

6890