SLC35D2抗体

SLC35D2抗体经ICC, IHC严格验证,品质保证.适用于多种种属反应性,被多篇文献引用并有用户反馈信息.确保特异性!产品具有以下特点:

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产品编号xy-20802R

英文名称SLC35D2

中文名称溶质载体家族蛋白35成员D2抗体

别    名Hfrc; HFRC1; Homolog of Fringe connection protein 1; MGC117215; MGC142139; Nucleotide sugar transporter UGTrel8; S35D2_HUMAN; S35D2_MOUSE; SLC35D2; Solute carrier family 35 member D2; SQV 7L; SQV7-like protein; SQV7L; UDP N acetylglucosamine transporter; UDP-galactose transporter-related protein 8; UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; UGTrel 8; UGTrel8.  

说 明 书100ul  200ul

研究领域

抗体来源Rabbit

克隆类型Polyclonal

SLC35D2抗体交叉反应 Mouse, Pig,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量37kDa

细胞定位细胞核 细胞浆

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from mouse SLC35D2

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

产品介绍background:

Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008]

Function:

Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling.

Subcellular Location:

Golgi apparatus membrane.

Tissue Specificity:

Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte. Weakly expressed in skeletal muscle and spleen. Not expressed in brain, colon and thymus.

Similarity:

Belongs to the TPT transporter family. SLC35D subfamily.

SWISS:

Q762D5

Gene ID:

70484