SIRT4抗体

SIRT4抗体经ICC, IHC严格验证,品质保证.适用于多种种属反应性,被多篇文献引用并有用户反馈信息.确保特异性!产品具有以下特点:

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产品编号xy-7537R

英文名称SIRT4

中文名称沉默调节相关蛋白4抗体

别    名NAD dependent deacetylase sirtuin 4; NAD-dependent ADP-ribosyltransferase sirtuin-4; Silent mating type information regulation 2 homolog; Sir 2 like 4; SIR 2 like protein 4; Sir2 like 4; SIR2 like protein 4; SIR2-like protein 4; SIR2L 4; SIR2L4; SIRT 4; Sirt4; SIRT4_HUMAN; Sirtuin (silent mating type information regulation 2 homolog) 4; Sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae); Sirtuin 4; Sirtuin type 4; Sirtuin4.  

JournalPMIDIFApplicationActa Oto-Laryngologica (2014)244601541.1060IHC-FActa oto-laryngologica (2015)264726591.0990Other

说 明 书100ul  200ul

研究领域心血管  细胞生物  信号转导  糖尿病  表观遗传学  

抗体来源Rabbit

克隆类型Polyclonal

SIRT4抗体交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Fruit Fly, Zebrafish

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量32kDa

细胞定位细胞浆

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from human SIRT4/SIR 2 like protein 4

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

产品介绍background:

NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down-regulates insulin secretion. Has no detectable protein deacetylase activity.

Function:

NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down-regulates insulin secretion. Has no detectable protein deacetylase activity.

Subunit:

Interacts with GLUD1, IDE and SLC25A5.

Subcellular Location:

Mitochondrion matrix.

Tissue Specificity:

Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes and fetal thymus.

Similarity:

Belongs to the sirtuin family. Class II subfamily.

Contains 1 deacetylase sirtuin-type domain.

SWISS:

Q9Y6E7

Gene ID:

23409