SFXN1抗体

SFXN1抗体经ICC, IHC严格验证,品质保证.适用于多种种属反应性,被多篇文献引用并有用户反馈信息.确保特异性!产品具有以下特点:

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产品编号xy-17306R

英文名称SFXN1

中文名称三羧酸载体蛋白SFXN1抗体

别    名FLJ12876; SFXN1; SFXN1_HUMAN; Sideroflexin 1; Sideroflexin-1; TCC; Tricarboxylate carrier protein.  

说 明 书100ul  200ul

研究领域肿瘤  细胞生物  神经生物学  信号转导  新陈代谢  

抗体来源Rabbit

克隆类型Polyclonal

SFXN1抗体交叉反应 Human, Mouse, Rat, Dog, Pig, Horse,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量36kDa

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from human SFXN1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

生 产 商BIOSS

PubMedPubMed

产品介绍background:

The sideroflexin (SFXN) family is comprised of SFXN1, SFXN2, SFXN3, SFXN4 and SFXN5. SFXN1, also designated tricarboxylate carrier protein TCC, is the most highly characterized family member. The ubiquitously expressed SFXN1 protein resides as an integral protein of the mitochondrial inner membrane. It functions as an essential component of the shuttle system that transports mitochondrial acetyl-CoA into the cytosol, where lipogenesis occurs. The SFXN1 gene is mutated in flexed-tail (f/f) mice, which display axial skeletal abnormalities and a transient embryonic and neonatal anemia characterized by pathologic intramitochondiral iron deposits in erythrocytes. Therefore, SFXN1 is also thought to facilitate the transport of a component required for iron utilization into mitochondria. All SFXN family members show expression in pancreatic islet cells. SFXN5 displays a citrate transport activity and is primarily expressed in brain.

Function:

Might be involved in the transport of a component required for iron utilization into or out of the mitochondria.

Subcellular Location:

Mitochondrion membrane.

Similarity:

Belongs to the sideroflexin family.

Gene ID:

94081